OUR SCIENCE

Transforming outcomes, one fusion at a time.

Redefining bone repair is our commitment. At Cerapedics, we drive this with the power of P-15 Osteogenic Cell Binding Peptide and the strength of rigorous clinical evidence.

See P-15 Osteogenic Cell Binding Peptide in action.

The power of P-15 Peptide is only found in Cerapedics spinal bone grafts.1

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IN THE HUMAN BODY

P-15 Peptide is a naturally occurring 15-amino acid sequence found in type-1 collagen and serves as a powerful cell attachment factor. 2-5

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AT CERAPEDICS

Pharmaceutically manufactured P-15 Peptide is bound onto calcium phosphate particles, creating a P-15 enhanced scaffold that provides an abundance of attachment sites for osteogenic cells.3-6

P-15 Peptide provides a distinct and proven mechanism of action, to attach and activate osteogenic cells to accelerate new bone formation.3-5,7,8

ATTACH

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Osteogenic cells attach to P-15 via specific surface receptors through high-affinity interactions on the cell surface, enhancing cell retention, spreading, and survival.2-5

ACTIVATE

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Once attached, cellular pathways are activated that enhance osteogenic activity by releasing growth factors and other important signaling molecules.2-4,9

ACCELERATE

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Upregulation of growth factors recruit additional osteogenic cells, creating a cyclical attachment and activation process that accelerates new bone formation.3-5,7-11

The proof behind P-15 peptide.

Clinical evidence sets bone graft products apart. Decades of rigorous research support how P-15 Peptide transforms the way bone grafts work.

View the evidence

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Research with us.

Be part of advancing bone repair by participating in ongoing research.

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References:

  1. i-FACTOR US Instructions for Use. Cerapedics.
  2. Hanks T, et al. Biochem Biophys Res Commun. 2003;311(1):179-186.
  3. Nguyen H, et al. Biochem Biophys Res Commun. 2003;311(1):179-186.
  4. Yang XB, et al. Tissue Eng. 2004;10(7-8):1148-1159.
  5. Liu Q, et al. J Orthop Res. 2012;10:1526.
  6. Cerapedics. Date on File.
  7. Thorwarth M, et al. Biomaterials. 2005;26(28):5648-5657.
  8. Lindley EM, et al. J Biomed Mater Res B Appl Biomater. 2010;94(2):463-468.
  9. Emecen P, et al. Acta Odontol Scand. 2009;67(2):65-73.
  10. Lind M, et al. Bone. 1996;18(1):53-57.
  11. Lee DH, et al. Tissue Eng. 2006;12(6):1577-1586.