The high affinity between cells and P-15 supports the physiological mechanism in which cells bind to collagen via the domain simulated by P-15 and continue to organize the matrix by tractional forces. Cells attach to and migrate on Type I collagen by haptotactic mechanisms.
i-FACTOR™ Bone Graft is based on the biological activity of the synthetically derived 15-amino acid peptide found naturally in Type I human collagen. This 15-amino acid peptide (P-15) is responsible for the attachment and proliferation of osteogenic cells. These cells have an affinity for and attach to the P-15 found in i-FACTOR™ Bone Graft in a similar way they would naturally with Type I collagen in bone.
i-FACTOR™ increases the opportunity for cell binding in the fusion site by making an abundance of P-15 available to osteogenic cells. The ability of P-15 to enhance cell binding hastens the process of new bone formation and closely resembles the natural process of bone regeneration. Once cells attach, to the P-15 immobilised on the ABM substrate, the cascade of events leading to new bone formation commences.