i-FACTOR and P-15

Product information and handling instructions

i-FACTOR Bone Graft is an advanced biologic that is supported with level I evidence, satisfies the highest regulatory imperatives, and provides a better cost/benefit ratio than engineered growth factors and cellular allografts.

i-FACTOR Bone Graft is the only biologic bone graft made of a synthetic small peptide (P-15) bound to an anorganic bone mineral (ABM). This unique combination creates a surface-bound “Attract, Attach, Activate” mechanism of action that enhances the body’s natural bone healing process. Being surface-bound, all cellular activity resulting from P-15 attachment is restricted to the implant surface so bone cannot grow where it doesn’t belong (ectopic bone growth).

i-FACTOR Bone Graft is not a morphogen so, unlike engineered growth factors, the signals sent following P-15 attachment in a bony site only activate cells that are pre-programmed to become osteoblasts.

i-FACTOR Bone Graft products are sterilized after packaging (terminally sterilized), can be stored at room temperature and have a three-year shelf life. i-FACTOR Bone Graft is ready to use and thus requires no mixing or other preparation prior to use.

The proof you require, the safety you demand.

Clinical Superiority

Clinical Superiority

Level 1 data supports your evidence based clinical decision making.

Peptide Power

Peptide Power

The only bone graft to harness the intense biological activity of a peptide (P-15).

Ready to use

Ready to use

Store at room temperature. Ready to use without mixing.

Fill and forget

Fill and forget

Don’t assume your bone graft will perform. Know it will.

Tried and trusted

Tried and trusted

FDA PMA approved (2015) drug device combination and has been CE Marked since 2008.

Safety by design

Safety by design

The unique P-15 action is surface bound and unlike growth factors only grows bone where you need it.

i-FACTOR Biologic Bone Graft novel mechanism of action enhances the body’s natural bone healing process, resulting in safe, predictable bone formation. ABM/P-15 has been in human clinical use for more than 17 years in an estimated 500,000 patients worldwide.

Learn more about the science

Mechanism of action

Key to choosing the appropriate graft material is an understanding of how it works. Learn more about the natural process and what to expect from i-FACTOR Bone Graft.

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Pre clinical

Studies have shown that P-15, in combination with ABM, mimics the behavior of autograft bone. Learn more about the depth of scientific research supporting this novel bone graft.

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Clinical

Research needs to translate into patient outcomes. Learn more about how i-FACTOR is transforming patients’ lives by providing clinicians with Level-1 data demonstrating the safety and efficacy of this new category of bone graft.

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