Discover how the novel
 i-FACTOR™ Bone Graft mechanism of action creates a safe and natural enhancement to the bone healing process.

i-FACTOR Bone Graft is the only biologic bone graft made of a synthetic small peptide (P-15) bound to an anorganic bone mineral (ABM). This unique combination creates a surface-bound “Attract, Attach, Activate” mechanism of action that enhances the body’s natural bone healing process. Being surface-bound, all cellular activity resulting from P-15 attachment is restricted to the implant surface so bone cannot grow where it doesn’t belong (ectopic bone growth).

i-FACTOR Bone Graft is not a morphogen so, unlike engineered growth factors, the signals sent following P-15 attachment in a bony site only activate cells that are pre-programmed to become osteoblasts.

 

 

Predictable Bone Growth

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  • Hole BB, Schwarz JA, Gilbert JL, Atkinson BL. A study of biologically active peptide sequences (P-15) on the surface of an ABM scaffold (PepGen P-15) using AFM and FTIR. J Biomed Mater Res A. 2005 Sep 15;74(4):712-21
  • Qian JJ, Bhatnagar RS. Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen. J Biomed Mater Res. 1996 Aug;31(4):545-54

Stem Cell Differentiation

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  • Turhani D, Weissenböck M, Watzinger E, Yerit K, Cvikl B, Ewers R, Thurnher D. In vitro study of adherent mandibular osteoblast-like cells on carrier materials. Int J Oral Maxillofac Surg. 2005 Jul;34(5):543-50. Epub 2005 Jan 26
  • Hennessy KM, Pollot BE, Clem WC, Phipps MC, Sawyer AA, Culpepper BK, Bellis SL. The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces. Biomaterials. 2009 Apr;30(10):1898-909
  • Yang XB, Bhatnagar RS, Li S, Oreffo RO. Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Eng. 2004 Jul-Aug;10(7-8):1148-59

Viable Cell Attachment

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  • Qian JJ, Bhatnagar RS. Enhanced cell attachment to anorganic bone mineral in the presence of a synthetic peptide related to collagen. J Biomed Mater Res. 1996 Aug;31(4):545-54
  • Turhani D, Weissenböck M, Watzinger E, Yerit K, Cvikl B, Ewers R, Thurnher D. In vitro study of adherent mandibular osteoblast-like cells on carrier materials. Int J Oral Maxillofac Surg. 2005 Jul;34(5):543-50. Epub 2005 Jan 26
  • Turhani D, Item C, Thurnher D, Kapral D, Cvikl B, Weissenböck M, Yerit K, Erovic B, Moser D, Watzinger F, Ewers R, Lauer G. [Evidence of osteocalcin expression in osteoblast cells of mandibular origin growing on biomaterials with RT-PCR and SDS-PAGE/Western blotting]. Mund Kiefer Gesichtschir. 2003 Sep;7(5):294-300. Epub 2003 Sep 12. German
  • Bhatnagar RS, Qian JJ, Wedrychowska A, Sadeghi M, Wu YM, Smith N. Design of biomimetic habitats for tissue engineering with P-15, a synthetic peptide analogue of collagen. Tissue Eng. 1999 Feb;5(1):53-65

Early Bone Formation

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  • Nguyen H, Qian JJ, Bhatnagar RS, Li S. Enhanced cell attachment and osteoblastic activity by P-15 peptide-coated matrix in hydrogels. Biochem Biophys Res Commun. 2003 Nov 7;311(1):179-86
  • Yang XB, Bhatnagar RS, Li S, Oreffo RO. Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Eng. 2004 Jul-Aug;10(7-8):1148-59
  • Hennessy KM, Pollot BE, Clem WC, Phipps MC, Sawyer AA, Culpepper BK, Bellis SL. The effect of collagen I mimetic peptides on mesenchymal stem cell adhesion and differentiation, and on bone formation at hydroxyapatite surfaces. Biomaterials. 2009 Apr;30(10):1898-909

Cell Proliferation

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  • Kübler A, Neugebauer J, Oh JH, Scheer M, Zöller JE. Growth and proliferation of human osteoblasts on different bone graft substitutes: an in vitro study. Implant Dentistry. 2004 June : 13(2) :171-9

Biomimetic Microenvironment

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  • Yang XB, Bhatnagar RS, Li S, Oreffo RO. Biomimetic collagen scaffolds for human bone cell growth and differentiation. Tissue Eng. 2004 Jul-Aug;10(7-8):1148-59
  • Thorwarth M, Schultze-Mosgau S, Wehrhan F, Kessler P, Srour S, Wiltfang J, Andreas Schlegel K. Bioactivation of an anorganic bone matrix by P-15 peptide for the promotion of early bone formation. Biomaterials. 2005 Oct;26(28):5648-57. Epub 2005 Apr 18